Jesse Kaye, Ph.D.

Ph.D., University of Wisconsin-Madison, 2018
M.S., University of Wisconsin-Madison, 2012
B.S., University of Wisconsin-Madison, 2007

Curriculum Vitae

Follow me on: PubMed, Google Scholar, LinkedIn, ResearchGate, Twitter @KayeJesseT, Publons, Open Science Framework

Research Interests
Broadly, I am interested in investigating the neurobiological mechanisms that underlie stress-reactivity in humans. I aim to apply this knowledge to inform our understanding of the etiology of addiction, particularly stress-induced relapse. To that end, I have employed a variety of laboratory based psychophysiological techniques ranging from event-related potentials to peripheral measures such as the eye blink startle response as well as complementary self-report ecological momentary assessment. My program of translational research aims to bridge basic science with clinical research to utilize innovative experimental medicine approaches that incorporates laboratory psychophysiology, psychopharmacology and clinical trials methodologies. Current research projects focus on screening the potential utility of noradrenergic alpha1 antagonists (e.g., prazosin, doxazosin) to treat stress-related relapse in alcohol and other substance use disorders.

Current Projects
Repurposing alpha1 noradrenergic antagonists for alcoholism treatment (F31, Principal Investigator)

Randomized controlled trial targeting noradrenergic stress mechanisms in alcoholism with doxazosin (R01, Significant Contributor)

Publications

Kaye JT, Bradford DE Magruder KP, & Curtin JJ (in press). Probing for neuroadaptations to unpredictable stresors in addiction: translational methods and emerging evidence. Journal of Studies on Alcohol and Drugs. PDF | OSF

Moberg CA, Bradford DE, Kaye JT, Curtin JJ (2017). Increased startle potentiation to unpredictable stressors in alcohol dependence: Possible stress neuroadaptation in humans. Journal of Abnormal Psychology, 126(4), 441-453. PMC5418084. PDF | OSF

Kaye JT, Bradford DE & Curtin JJ (2016). Psychometric properties of startle and corrugator response in NPU, Affective Picture Viewing, and Resting State tasks. Psychophysiology, 53(8), 1241-1255. PDF | OSF | Supplemental Information
Bradford DE, Kaye JT, Curtin JJ (2014). Not just noise: Individual differences in general startle reactivity predict startle reactivity to uncertain and certain threat. Psychophysiology, 51, 407-411. PMC3984356. PDF | Study Highlights

Henry EA, Kaye JT, Bryan AD, Hutchison KE, Ito TA, (2014). Cannabis Cue Reactivity and Craving Among Never, Infrequent and Heavy Cannabis Users. Neuropsychopharmacology, 39, 1214-1221. PMID: 24264815.  PDF

Piper ME, Schlam TR, Cook JW, Sheffer MA, Smith SS, Loh W, Bolt DB, Kim S, Kaye JT, Hefner KR, Bake BT (2011). Tobacco withdrawal components and their relations with relapse vulnerability. Psychopharmacology, 216, 569-578. PMID: 21416234.  PDF

McFadden KL, Healy KM, Dettmann ML, Kaye JT, It TA, Hernández TD (2011) Acupressure as a non-pharmacological intervention for traumatic brain injury (TBI). Journal of Neutotrauma, 28, 21-34. PMID: 20979460.  PDF

Ito TA, Willadsen-Jensen EC, Kaye JT, Park B (2011). Contextual variation in automatic evaluative bias to racially-ambiguous faces. Journal of Experimental Social Psychology, 47, 818-823. PMC3117667.  PDF

Hogle JM, Kaye JT, Curtin JJ (2010). Nicotine withdrawal increases threat-induced anxiety but not fear: Neuroadaptation in human addiction. Biological Psychiatry, 68, 719-725. PMC2949532 PDF | Supplemental Information | Study Highlights

Posters & Presentations

Kaye JT, Bradford DE, Curtin JJ (2016). Psychometric challenges for psychophysiology in the age of RDoC. Chaired symposium at the Society for Psychophysiological Research (SPR) Annual Meeting, Minneapolis, MN.

Kaye JT, Bradford DE, Curtin JJ (2016). Psychometric properties and inter-task/measure relationships of startle and corrugator response in NPU, Affective Picture Viewing, and Resting State tasks. Poster presented at the Society for Psychophysiological Research (SPR) Annual Meeting, Minneapolis, MN. PDF Powerpoint

* Kaye JT, Bradford DE, Curtin JJ (2016). Psychometric properties of psychophysiological paradigms in the NIMH RDoC: startle and corrugator response in NPU, affective picture viewing, and resting state tasks. Poster presented at the Association for Psychological Science annual convention, Chicago, IL. PDF | OSF
*SSCP Student Poster Award

Kaye JT, Kayser AD, Schneck SE, Bradford DE, Curtin JJ (2016). No shock, predictable shock, unpredictable shock (NPU) task: Psychometric properties of startle and corrugator potentiation. Poster presented at the Wisconsin Symposium on Emotion, Madison, WI. PDF

Kaye JT, Bradford DE, Curtin JJ (2016). Psychometric properties of startle response modulation in three tasks from the NIMH RDoC Negative Valence System. Poster presented at the Society for Affective Science Conference, Chicago, IL.

Kaye JT, Schneck SE, Kayser AD, Bradford DE, Curtin JJ (2016). Affective picture viewing task: Psychometric properties of startle and corrugator potentiation. Poster presented at the Wisconsin Symposium on Emotion, Madison, WI. PDF

Kaye JT, Bradford DE, Rohrer CT, Hamilton RK, Kayser AD, Curtin JJ (2015). Psychometric properties of startle response modulation during threat-of-shock, affective picture viewing, and resting state tasks. Poster presented at the Society for Psychophysiological Research annual meeting, Seattle, WA. PDF

Kaye JT, Curtin JJ (2014). Repurposing norepinephrine antagonists for drug addiction treatment: A novel translational laboratory biomarker approach. Poster presented at Wisconsin Symposium on Emotion annual meeting, Madison, WI.PDF

Kaye JT, Curtin JJ (2014). Repurposing norepinephrine antagonists for drug addiction treatment: A novel translational laboratory biomarker approach. Poster presented at the Symposium on Therapeutics Discovery & Development, UW Institute of Clinical and Translational Research, Madison, WI. PDF

Kaye JT, Shi FY, Baker TB, Curtin JJ (2013). Nicotine deprivation induces negative affect to actual cigarettes but not pictures of cigarettes. Poster presented at the Society for Psychophysiological Research annual meeting, Florence, Italy. PDF

Henry EA, Bryan AD, Kaye JT, Ito TA (2013). On the liking and wanting of cannabis: examining the joint effects of attitudes and cue reactivity among cannabis users. Poster presented at the annual meeting for the Society for Psychophysiological Research, Florence, Italy.  PDF

Kaye JT, Williams WC, Hachiya LY, Bradford DE, Curtin JJ. (2011). Affective response to differential threat probabilities is unaffected by nicotine deprivation. Poster presented at the Society for Psychophysiological Research annual meeting, Boston, MA.PDF

* Bradford DE, Kaye JT, Curtin JJ (2011). Not Just Noise: Individual Differences in Baseline Startle are Anxiety Revelant. Poster Poster presented at the Society for Psychophysiological Research annual meeting, Boston, MA. PDF
* SPR Student Poster Award

McFadden KL, Healy KM, Dettmann ML, Kaye JT, Ito TA, Diste DF, Faes N, Hernández TD (2011). Acupressure efficacy as a non-pharmacological intervention for traumatic brain injury (TBI). Poster presented at the annual meeting for the American Neuropsychiatric Association, Denver, CO.

* Kaye JT, Ito TA (2010). Differential Marijuana Cue Reactivity in the Late-Positive Potential in Smokers and Non-Smokers. Poster presented at the 50th annual meeting of the Society for Psychophysiological Research, Portland, OR.
* SPR Student Poster Award

Kaye JT, Busch JTA, Ito TA (2010). Enhanced Attentional Bias to Visual Marijuana Cues in Smokers Indicated by Event-Related Potentials. Poster presented at the 4th annual meeting of the Social and Affective Neuroscience Society, Chicago, IL. PDF

Kaye JT, Ito TA (2009). Response Inhibition and Error Monitoring Deficits Associated with Marijuana Use. Poster presented at the 3rd annual meeting of the Social and Affective Neuroscience Society, New York City, NY.  PDF

Curtin JJ, Hogle JM, Kaye JT (2007). Negative affect during nicotine withdrawal. Neurobiology of Addiction conference. Santa Fe, NM.

Hogle JM, Curtin JJ, Kaye JT (2007). Negative Affect During Nicotine Withdrawal: Insights from Explicit-cue and Contextual Fear Conditioning Models. Poster presented at the Society for Research on Nicotine and Tobacco annual meeting.